دكتوراه بحثية في جامعة ستراسبورغ.

في حين إن أغلبنا يطمح إلى إنجازات علمية متفردة ويبحث عما يساعده في الوصول إلى غايته، تساهم المنح العلمية المقدمة من الحكومات أو المؤسسات غير الحكومية في بلوغ أهدافنا ولكن كثيراً ما نحتاج إلى دليل يرشدنا لنيل هذه المنحة أو تلك وانطلاقاً من إيمان (الباحثون السوريون) بشعارنا العلم هو الحل ننشر لكم فرصة مقعد دكتوراه بحثي في جامعة ستراسبورغ من الوكالة الوطنية للأبحاث في فرنسا، تهدف إلى البحث المخبري في علم العقاقير ومراقبة في مستوى الجزيء في التغييرات المحلية للأحماض الأمينية في فرنسا بإشراف (Pr.Yves Mely and Pascal Didier) مدة ثلاث سنوات.

موعد انتهاء التقديم: 30 أيلول 2017

هنا

للتقديم إرسال السيرة الذاتية إلى:

yves.mely@unistra.fr

pascal.didier@unistra.fr

للمزيد من التفاصيل إليكم نص الإعلان:

PhD position at the University of Strasbourg

UMR 7213 CNRS, Laboratoire de Biophotonique et Pharmacologie

Faculté de Pharmacie

74 route du Rhin

F - 67401 Illkirch

هنا- strasbg.fr

Site-selective faithful monitoring at the single molecule level of local changes in nucleic acids

Applications are being sought for a 3 years PhD position in the Laboratory of Biophotonics

and Pharmacology in Strasbourg, France (هنا). The project is funded

by The French National Research Agency and will be carried out under the supervision of Pr

Yves Mély and Pascal Didier.

We are seeking a highly motivated student with expertise in fluorescence and microscopy,

with a keen interest in applying this knowledge to biology and notably nucleic acids.

Fluorescent labelling of nucleic acids has been revolutionized by the introduction of

deoxythienoguanosine, thG, a truly faithful surrogate for G, which reproduces the structural

context and dynamics of the native nucleotide and remains well fluorescent in nucleic acids.

Moreover, thG exhibits an environment sensitive emission that opens a fantastic range of

applications. In this project, our ambition is to apply this outstanding probe in single

molecule measurements, in order to faithfully monitor for the first time local changes in

nucleic acids on a single molecule level. To reach this challenging aim, we will enhance thG

emission and photostability using surface plasmon resonance together with DNA origamis to

precisely control the metal/fluorophore distance. The developed system will be used to

characterize the poorly understood dynamics of the successive molecular steps involved in

the replication of the DNA methylation pattern by the UHRF1/DNMT1 tandem. This thG-

based single molecule fluorescence approach will help solving a large range of biological

questions involving local and transient structural nucleic acid changes. Moreover, the

deciphering of the molecular mechanism of the base flipping steps in DNA methylation

replication by the UHRF1/DNMT1 tandem should provide new clues on its possible blockage

and thus, lead to major therapeutic applications in pathologies, such as cancers and

neurodegenerative diseases, where the methylation profile is modified.

We are looking for creative students that can contribute with their own ideas and proposals.

Candidates having a master of physics or biophysics or physicochemistry should send a

detailed CV to yves.mely@unistra.fr or pascal.didier@unistra.fr.

Deadline for application : September 30, 2017